Integration in Immunology: From DNA Repair to Immune Regulation

Günnur Deniz

Immunology is no longer confined to the study of defense—it is now recognized as an integrated system linking genome integrity, cellular stress, and disease. The first issue of the year reflects reflects this evolving perspective and marks an important milestone for the Turkish Journal of Immunology (TJI). We are particularly honored to welcome Prof. Aziz Sancar to our editorial board.(...)

April 30, 2026

Review Article

Respiratory Viral Coinfections: Impacts on Virus Replication and Host Immune Response

Fariba Shokri

and others

Coinfection is common among respiratory viral infections and can result in severe symptoms in affected patients. The global prevalence of viral coinfection is still unknown; however, interest in this topic has increased in recent years. Studies have estimated a coinfection rate of 5.01% among patients (...)

April 30, 2026

Original Research

The Correlation Between the Onset of Autoimmune Inflammatory Response and Gouty Arthritis

Rojan G.M.AL-Allaff

and others

Gouty arthritis is a complex inflammatory condition associated with metabolic derangements and an enhanced innate immune response. Gout is caused by the accumulation of monosodium urate (MSU) crystals in the synovial fluid and joint tissues. However ,the transition from asymptomatic hyperuricemia to an acute, self-limiting (...)

April 30, 2026

April 2026 VOLUME 14 | ISSUE 1

ISSN 1301-109X | e-ISSN 2147-8325

Original Research

Asparagine Endopeptidase (AEP) Promotes Type I IFN Expression via the cGAS-STING Pathway by Suppressing the Activity of Apoptotic Caspases

Inam Ullah Khan

and others

Type I interferons (IFNs) play a critical role in suppressing the spread of viral infection. Viral infection triggers systemic immune responses in host cells, leading to the activation of different transcriptional factors and the production of various cytokines (...)

April 30, 2026

Editorial

The NER–STING Axis: When DNA Repair Becomes Immune Signaling A Perspective for the Turkish Journal of Immunology

Aziz Sancar

When I began studying how cells repair ultraviolet (UV)-induced DNA damage, the objective was precise and mechanistic: to understand how damaged DNA is recognized and corrected at the molecular (...)

April 30, 2026

Original Research

Comparative Evaluation of Magnetic Cell Separation Systems Based on Cell Recovery and CD14 mRNA Enrichment

Arzuhan Büyüker

and others

Magnetic cell sorting is a rapid and reliable technique commonly used to isolate specific cell types from blood or tissue samples. Anti-CD14 magnetic beads are commonly employed in positive selection strategies, as CD14 is predominantly expressed in (...)

April 30, 2026

Original Research

A Preliminary Study on Soluble Immune Checkpoint Proteins in Systemic Lupus Erythematosus and Sjögren's Syndrome Patients

Ege Gürlü

and others

Immune checkpoint proteins (ICPs) regulate mechanisms that are critical for maintaining immune tolerance. The first ICP was discovered in the early 1990s, and over the past two decades, extensive research has underscored the importance of ICPs (...)

April 30, 2026