CURRENT ISSUE
Editorial
Integration in Immunology: From DNA Repair to Immune Regulation
Günnur Deniz
Immunology is no longer confined to the study of defense—it is now recognized as an integrated system linking genome integrity, cellular stress, and disease. The first issue of the year reflects reflects this evolving perspective and marks an important milestone for the Turkish Journal of Immunology (TJI). We are particularly honored to welcome Prof. Aziz Sancar to our editorial board.(...)
The NER–STING Axis: When DNA Repair Becomes Immune Signaling A Perspective for the Turkish Journal of Immunology
Aziz Sancar
When I began studying how cells repair ultraviolet (UV)-induced DNA damage, the objective was precise and mechanistic: to understand how damaged DNA is recognized and corrected at the molecular (...)
Review Article
Respiratory Viral Coinfections: Impacts on Virus Replication and Host Immune Response
Fariba Shokri
Coinfection is common among respiratory viral infections and can result in severe symptoms in affected patients. The global prevalence of viral coinfection is still unknown; however, interest in this topic has increased in recent years. Studies have estimated a coinfection rate of 5.01% among patients (...)
and others
Original Research
Asparagine Endopeptidase (AEP) Promotes Type I IFN Expression via the cGAS-STING Pathway by Suppressing the Activity of Apoptotic Caspases
Inam Ullah Khan
Type I interferons (IFNs) play a critical role in suppressing the spread of viral infection. Viral infection triggers systemic immune responses in host cells, leading to the activation of different transcriptional factors and the production of various cytokines (...)
and others
A Preliminary Study on Soluble Immune Checkpoint Proteins in Systemic Lupus Erythematosus and Sjögren's Syndrome Patients
Ege Gürlü
Immune checkpoint proteins (ICPs) regulate mechanisms that are critical for maintaining immune tolerance. The first ICP was discovered in the early 1990s, and over the past two decades, extensive research has underscored the importance of ICPs (...)
and others
The Correlation Between the Onset of Autoimmune Inflammatory Response and Gouty Arthritis
Rojan G.M.AL-Allaff
Gouty arthritis is a complex inflammatory condition associated with metabolic derangements and an enhanced innate immune response. Gout is caused by the accumulation of monosodium urate (MSU) crystals in the synovial fluid and joint tissues. However ,the transition from asymptomatic hyperuricemia to an acute, self-limiting (...)
and others
Comparative Evaluation of Magnetic Cell Separation Systems Based on Cell Recovery and CD14 mRNA Enrichment
Arzuhan Büyüker
Magnetic cell sorting is a rapid and reliable technique commonly used to isolate specific cell types from blood or tissue samples. Anti-CD14 magnetic beads are commonly employed in positive selection strategies, as CD14 is predominantly expressed in (...)
and others