Objectives:

In this study, we investigated the acidic mammalian chitinase (AMCase) gene expression in skin biopsy samples taken from patients with atopic dermatitis.

Patients and methods:

Five adult patients with atopic dermatitis were enrolled in this study between May 2005 and May 2007. Skin biopsy samples were taken from lesional and unaffected areas. AMCase gene expression was tested by real-time polymerase chain reaction. The AMCase gene products were compared with beta-actin.

Results:

The AMCase production was higher in healthy regions of skin compared to the samples taken from atopic lesion. The AMCase gene expression was isolated in healthy and atopic skin regions.

Conclusion:

The AMCase gene expression was isolated both skin regions. Our study shown that this gene is not only expressed stomach and lung and also expressed in skin.

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