Fahimeh Khadem
Nafiseh Esmaeil
Abbas Rezaei
Hossein Motadayen
Behnaz Khani

Abstract

Introduction:

Introduction: Unexplained Recurrent Spontaneous Abortion (URSA) is the most common immunological complication during pregnancy. It has been found that the cells such as human amnion epithelial cells (hAECs) have the potency to modulate immune responses in vitro and in vivo. In the present study, we assessed the immunomodulatory effect of hAECs on NK cells and T cells in women with URSA.

Results:

We found that CD69 activating receptor expression on NK cells and T cells was significantly decreased by incubation with hAECs in a dose-dependent manner (p=0.049). Also, the degranulation marker CD107a was significantly downregulated on NK cells and T cells following incubation with hAEC (p=0.003).

Conclusion:

Our results suggest hAECs have immune regulatory effects on activation and cytotoxicity of NK and T cells. Potential therapeutic application of hAECs for dysregulated NK and T cells immunity should be investigated in the future.

Keywords:

Human amnion epithelial cells (hAECs), Unexplained recurrent spontaneous abortion (URSA), Immunomodulation, Natural killer cell, T cell

VOLUME

7

,

ISSUE

1
April 2019

Correspondence

Nafiseh Esmaeil

Email

nafesm5@gmail.com

Received

Accepted

Published

Suggested Citation

DOI

License

This work is licensed under the Creative Commons Attribution-NonCommercial-Non-Derivatives 4.0 International License (CC BY-NC-ND 4.0). License