Turk J Immunol. 2024; 12(1): 1-5 | DOI: 10.4274/tji.galenos.2024.00001

Tracing the Spectrum of Inborn Errors of Immunity from Past to Present

Safa Barýþ¹, Talal A. Chatila^2
1Division of Pediatric Allergy and Immunology, Marmara University Faculty of Medicine, Ýstanbul, Turkey, Ýstanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Marmara University, Ýstanbul, Turkey and The Iþýl Berat Barlan Center for Translational Medicine, Marmara University, Ýstanbul, Turkey
²Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA

Human inborn errors of immunity (IEI) constitute a constellation of genetic disorders with profound implications for immune system function, leading to recurrent infections, immune dysregulations, and malignancies. The field of IEI has undergone a tremendous evolution over the course of seventy years, with substantial strides in comprehending the clinical and immunological aspects of monogenic disorders. Furthermore, these endeavors have synergized with innovative therapeutic modalities, forging a trajectory toward enhanced patient care. These advances promise to favorably transform the outcomes of many IEI to provide patients with increased life expectancy and improved quality of life. In this special issue of the Turkish Journal of Immunology, we will survey some recent advances in the field of IEI with a focus on disease pathogenesis and outcomes.

Keywords: Inborn errors of immunity, primary immune deficiencies, diagnosis, treatment, outcome

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