Turk J Immunol. 2018; 6(1): 23-29 | DOI: 10.25002/tji.2018.684

Effect of Ophiocephalus striatus Extract on the Levels of TNF-?, CRP, Leptin, Adiponectin, and COPD Assessment Test (CAT) Score in Stable COPD Patients with Muscle Wasting

Djajalaksana Susanthy¹, Kusumawardhani Erna¹, Widiasari Komang Sri Rahayu¹
Faculty of Medicine, Brawijaya University, Malang, Indonesia, Department of Pulmonology and Respiratory Medicine, Malang, Indonesia

Introduction: Muscle wasting is an extrapulmonary manifestation that occurs in 20–40% of patients with Chronic Obstructive Pulmonary Disease (COPD). The purpose of this study is to confirm whether nutrition support can improve inflammation (measured by levels of TNF-?, CRP, leptin, and adiponectin), muscle wasting, and quality of life of COPD patients with muscle wasting. Material and Methods: The study design was a clinical pre-and post-auto-control quasi-experimental, conducted with a sample of stable COPD patients with comorbid muscle wasting. Muscle wasting was diagnosed through examination of the Bioelectrical Impedance Analysis (BIA). Levels of leptin and adiponectin were measured using the Enzymelinked immunosorbent assay (ELISA) method, and quality of life was assessed using COPD Assessment Test (CAT) score. BIA, TNF-?, CRP, leptin, adiponectin, and CAT were measured in 32 COPD patients with muscle wasting, before and after 12 weeks supplementation with Ophiocephalus striatus extract, 3x1000 mg/day. Results: There was a significant increase in body-mass index (BMI) (p=0.046), no significant increase in Fat-free mass index (FFMI) (p=0506), no significant decrease in TNF-? and CRP, a significant decrease in leptin levels (p <0.001), a significant increase in adiponectin levels (p=0.048), and a significant improvement in quality of life (score CAT) (p <0.001) after administration of Ophiocephalus striatus extract for 12 weeks. Conclusion: Supplementation with Ophiocephalus striatus extract for 12 weeks can improve BMI, decrease levels of TNF-?, CRP, and leptin, increase the level of adiponectin, and result in improvement in the quality of life of stable COPD patients with muscle wasting.

Keywords: Adiponectin, Chronic Obstructive Pulmonary Disease, Leptin, Muscle wasting, Ophiocephalus striatus extract

---

Ophiocephalus striatus Ekstresinin Kas Erimesi Olan Stabil Kronik Obstrüktif Akciðer Hastalarýnda TNF-alfa, CRP, Leptin ve Adiponektin Düzeylerine Olan Etkisi

Djajalaksana Susanthy¹, Kusumawardhani Erna¹, Widiasari Komang Sri Rahayu¹
Faculty of Medicine, Brawijaya University, Malang, Indonesia, Department of Pulmonology and Respiratory Medicine, Malang, Indonesia

Giriþ: Kronik Obstrüktif Akciðer Hastalýðý (KOAH) bulunan olgularýn %20-40’ýnda kas erimesi bulunmaktadýr. Bu çalýþmanýn amacý, KOAH’lý hastalarda yapýlan beslenme desteðinin, (TNF-?, CRP, leptin ve adiponektin ile ölçülebilen) yangýyý azaltýp azaltmadýðýný ve kas erimesi ile hayat kalitesine olan etkisini araþtýrmaktýr. Gereçler ve Yöntemler: Çalýþma, kas erimesi olan ve KOAH’ý bulunan hastalarda önce ve sonra kontrollü yarý deneysel bir klinik çalýþma olarak tasarlandý. Kas erimesi, Bioelektrik empedans analizi ile (BEA) ölçüldü. eptin ve adiponektin düzeyleri ELISA metodu ile, hayat kalitesi ise, KOAH Deðerlendirme Testi (KDT) ile saptandý. BEA, TNF-?, CRP, leptin adiponektin ve KDT ölçümleri, 32 hastada, 12 hafta boyunca günde 3 kez 1000mg Ophiocephalus striatus ekstresi verilmeden ve verildikten sonra ölçüldü. Bulgular: On iki hafta boyunca Ophiocephalus striatus ekstresi verildikten sonra vücud kitle indeksinde (p=0.046) anlamlý bir artýþ olur iken, yaðsýz kitle indeksi(YKÝ)’nde(p=0.506), TNF-?, CRP düzeylerinde ise belirgin bir artýþ saptanmadý. Hayat kalitesi ölçümlerinde (KDT) ise anlamlý bir artýþ (p<0.001) bulundu. Sonuç: On iki hafta boyunca Ophiocephalus striatus ekstresi verilmesi, VKÝ’ni artýrmakta, TNF-?, CRP, leptin düzeylerini düþürmekte adiponektin düzeyini artýrarak, kas erimesi olan KOAH hastalarýnda hayat kalitesini yükseltmektedir.

Anahtar Kelimeler: Adiponektin, Kronik obstrüktif akciðer hastalýðý (KOAH), leptin, kas erimesi, Ophiocephalus striatus ekstresi

---

CITE