Turk J Immunol. 2021; 9(1): 28-35 | DOI: 10.5222/TJI.2021.22931

Effect of Hypnotherapy on Immune Response and Standard Therapy in Psychogenic Asthma Patients

Yusup Subagio Sutanto¹, Handono Kalim², Kusworini Handono³, Aris Sudiyanto^4
1Sebelas Maret University, Department of Pulmonology and Respiratory Medicine, Surakarta, Indonesia
²Brawijaya University, Department of Internal Medicine, Malang, Indonesia
³Brawijaya University, Department of Clinical Pathology, Malang, Indonesia
⁴Sebelas Maret University, Department of Psychiatry, Surakarta, Indonesia

Objective: Asthma is a complex inflammatory disease. The therapy for asthma is usually pharmacotherapy but it can increase the side effects in the long run. Hypnosis has been used to clinically treat asthma. This study aimed to investigate the efficacy of hypnotherapy which will increase the standard of therapy in psychogenic asthma patients on immune response, stress mediators, and asthma control level.
Materials and Methods: This research is a double-blind experimental randomized control trial group study with a crossover design conducted in the outpatient clinic of Dr. Moewardi Hospital, Surakarta, Indonesia. The Friedman test followed by the marginal homogeneity statistic test was used to assess variations in the levels of asthma control. The study subjects were 30 respondents who were divided randomly into groups A and B. Both groups had standard asthma therapy and hypnotherapy with a different sequence.
Results: Hypnotherapy made a significant decrease in SCL 90 score within each group as follows: Group A (A1 vs A2; p=0.004) and Group B (B2 vs B3; p=0.001). Levels of asthma control improved significantly in both groups (A1 vs A2; p=0.001 and B2 vs B3; p=0.004). Hypnotherapy significantly improved the norepinephrine levels in both groups as well (A1 vs A2; p=0.001 and B2 vs B3; p=0.073). Hypnotherapy insignificantly reduced IL-13 (p=0.132) and IL-17 (p=0.149) levels.
Conclusion: This study concluded that hypnotherapy applied to psychogenic asthma patients can improve their standard therapy response. This improved standard therapy response will affect the treatment, prevention, and management of uncontrolled asthma.

Keywords: asthma control level, cortisol, hypnotherapy, IL-13, norepinephrine, psychogenic asthma

---

Psikojen Astým Hastalarýnda Ýmmün Cevap ve Standart Tedavi Üzerinde Hipnoterapinin Etkisi

Yusup Subagio Sutanto¹, Handono Kalim², Kusworini Handono³, Aris Sudiyanto^4
1Sebelas Maret University, Department of Pulmonology and Respiratory Medicine, Surakarta, Indonesia
²Brawijaya University, Department of Internal Medicine, Malang, Indonesia
³Brawijaya University, Department of Clinical Pathology, Malang, Indonesia
⁴Sebelas Maret University, Department of Psychiatry, Surakarta, Indonesia

Amaç: Astým, kompleks inflamatuvar bir hastalýktýr. Astým tedavisi genellikle farmakoterapidir ancak uzun vadede yan etkileri arttýrabilir. Hipnoz, astýmýn klinik olarak tedavi edilmesi için kullanýlmaktadýr. Bu çalýþmanýn amacý, immün cevap, stres mediatörleri ve astým kontrol seviyesine iliþkin olarak psikojen astým hastalarýnda tedavi standardýný arttýracak olan hipnoterapinin etkililiðini araþtýrmaktýr.
Gereç ve Yöntem: Bu araþtýrma, Surakarta, Endonezya’da bulunan Dr. Moewardi Hastanesinin polikliniðinde yürütülen çapraz tasarýmlý bir çift kör, deneysel, randomize kontrollü bir deney grubu çalýþmasýdýr. Astým kontrolü seviyelerindeki varyasyonlarý deðerlendirmek için Friedman testi ve ardýndan marjinal homojenlik testi kullanýldý. Çalýþmada rastgele yöntem ile A ve B gruplarýna ayrýlmýþ 30 hasta yer aldý. Her iki grup da, farklý bir sýrayla standart astým tedavisi ve hiponoterapi aldý.
Bulgular: Hipnoterapi, aþaðýda belirtilen þekilde her grup içinde SCO 90 skorlarýnda anlamlý bir azalma saðladý: Grup A (A1 vs A2; p=0.004) ve Grup B (B2 vs B3; p=0.001). Astým kontrol seviyeleri, her iki grupta da anlamlý olarak iyileþme gösterdi (A1 karþý A2; p=0.001 ve B2 karþý B3; p=0,004). Hipnoterapi, yine her iki grupta, norepinefrin seviyelerini anlamlý olarak iyileþtirdi (A1 karþý A2; p=0.001 ve B2 karþý B3; p=0.073). Hipnoterapi, IL-13 (p=0.132) ve IL-17 (p=0.149) seviyelerini istatistiksel olarak anlamlý olmayan düzeylerde azalttý.
Sonuç: Bu çalýþma, psikojen astým hastalarýna uygulanan hipnoterapinin standart tedaviye verdikleri yanýtý iyileþtirebildiði sonucuna varmýþtýr. Bu geliþmiþ standart tedavi yanýtý da kontrolsüz astýmýn tedavisini, önlenmesini ve tedavisini etkileyecektir.

Anahtar Kelimeler: astým kontrol seviyesi, kortizol, hipnoterapi, IL-13, norepinefrin, psikojenik astým

---

CITE