Turk J Immunol. 2018; 6(2): 47-51 | DOI: 10.25002/tji.2018.564

Interferon-g and Interleukin-4 Expression in Chronic Rhinosinusitis

Bestari Jaka Budiman¹, Surya Azani¹, Effy Huriyati¹, Dolly Irfandy¹, Andani Putra¹
Andalas University School of Medicine, Padang, Sumatera Barat 25163, Indonesia., School of Medicine, Padang, Indonesia

Introduction: This study aims is to determine the Interleukin-4 (IL-4) and Interferon-? (IFN-?) expression in Chronic rhinosinusitis (CRS) with and without nasal polyps. Matarial and Methods: In the study, we analyzed the findings of 27 pair pathologic specimens of patients with CRS. Concha nasalis media smear was used to determine the IL-4 and IFN-? expression by real-time polymerase chain reaction (RT-PCR). Data were analyzed by cytokine gene absolute log copy number (CN). Results: Both IL-4 and IFN-? in patients with CRS with nasal polyps CN mean Log of CRS with nasal polyps were higher (15.28±3.92 and 8.54±2.96, respectively) than those of CRS without polyps (14.65±4.65 and 7.57±1.82, respectively), but this was not statistically significant (p=0.596, 0.346 respectively). Conclusion: IL-4 and IFN-? absolute expression level are higher in CRS with nasal polyps than those who had CRS without nasal polyps, but this was not statistically significant (p>0.05).

Keywords: Chronic rhinosinusitis, IL-4, IFN-?, nasal polyps

---

Kronik Rinosinüzitte Ýnterferon-g ve Ýnterlökin-4 Ýfadesi

Bestari Jaka Budiman¹, Surya Azani¹, Effy Huriyati¹, Dolly Irfandy¹, Andani Putra¹
Andalas University School of Medicine, Padang, Sumatera Barat 25163, Indonesia., School of Medicine, Padang, Indonesia

Giriþ: Bu çalýþmada nazal polipi olan ve olmayan kronik sinüzitli (KZ) hastalarda interferon-? (IFN-?) düzeylerinin saptanmasý amaçlandý. Gereç ve Yöntemler: Bu çalýþmada KZ’i bulunan 27 çift hastanýn patolojik piyesleri irdelendi. IL-4 ve IFN-? ölçümleri, medial nazal konkadan elde edilen sürüntü örneklerinde gerçek zamanlý polimeraz zincir reaksiyonu yöntemi kullanýlarak yapýldý. Saptanan gen kopya sayýlarýnýn logaritmalarý karþýlaþtýrýldý. Bulgular: Nazal polipi olan KZ hastalarýnda Il-4 ve IFN-? seviyeleri, ayný hastalýðý olan nazal polipsiz olgularýn düzeylerine göre daha yüksek bulundu ancak, aradaký fark istatistiksel olarak anlamlý deðil idi (sýrasýyla, p=0.596 ve 0.346). Sonuç: Nazal polipi olan KZ’li hastalardaki Il-4 ve IFN-? düzeyleri, polipi olmayanlara göre daha yüksek olmak ile birlikte aradaki fark anlamlý deðildir.

Anahtar Kelimeler: Kronik rinosinüzit, IL-4, IFN-?, nazal polip

---

CITE