Turk J Immunol. 2018; 6(1): 37-46 | DOI: 10.25002/tji.2018.774

Multiple Sclerosis Under Attack; Shehata’s Therapy

Mohamed Shehata Ali Mohamed¹
University of Cologne, General Medicine, Cologne, Germany

Multiple sclerosis is an autoimmune disease characterized by inflammatory demylination of the nerves in the central nervous system (brain and spinal cord). Depending on the attacked sites, the disease manifestations vary from limited sensory and/or motoric deficits to wide spread neurological and cognitive deficits. Similar to other autoimmune neurological and non-neurological diseases, the available therapeutic strategies rely on the pharmacological modulation of the immunity, which could be associated with significant side effects. In this paper, the light will be shed on another innovative therapeutic strategy that rely on the biological modulation of the immune responses, together with the inhibition of the recruitment of the immune cells into the central nervous system after distortion of the blood brain barrier, as well as the enhancement of the regenerative ability towards the restoration of efficient blood brain barrier and the regenerative recovery of the neurological deficits.

Keywords: Multiple sclerosis, autoimmunity, regenerative therapy, mesenchymal stem cells and fibrinogen

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Multipl Skleroz Saldýrý Altýnda: Shehata’nýn Tedavisi

Mohamed Shehata Ali Mohamed¹
University of Cologne, General Medicine, Cologne, Germany

Multipl skleroz, merkezi sinir sistemindeki sinirlerin (beyin ve omurilikteki) inflamatuvar olarak demyelinizasyonu ile oluþan bir hastalýktýr. Hastalarda, etkilenen bölgeye baðlý olarak, sýnýrlý motor ve duyusal ileti kusurundan, yaygýn nörolojik ve biliþsel kýsýtlýlýða kadar farklý problemler görülebilmektedir. Diðer nörolojik olan ve olmayan otoimmün hastalýklarda olduðu gibi, tedavi, önemli istenmeyen yan etkileri de olan baðýþýklýk sisteminin farmakolojik olarak düzenlenmesi ile yapýlmaktadýr. Bu makale, beyine kan beyin bariyeri bozulduktan sonra toplanan baðýþýklýk hücrelerinin baskýlanmasýný saðlayan baðýþýklýk yanýtýnýn biyolojik olarak düzenlenmesi gibi yaratýcý tedavi yöntemleri ile, bu yöntemlerin zarar görmüþ olan kan beyin bariyerini ve nörolojik problemleri düzeltebilme yetenekleri konusundaki bilgilere ýþýk tutacaktýr.

Anahtar Kelimeler: Multipl skleroz, otoimmünite, yeniden üretici (rejeneratif ) tedavi, mezenkimal kök hücreler, fibrinojen

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