ISSN 1301-109X | e-ISSN 2147-8325
Human Leukocyte Antigen Class I-II Allele Frequencies and Association Between Human Leukocyte Antigen Alleles and ABO Blood Group Antigens [Turk J Immunol]
Turk J Immunol. 2016; 4(1): 14-18 | DOI: 10.5606/tji.2016.464

Human Leukocyte Antigen Class I-II Allele Frequencies and Association Between Human Leukocyte Antigen Alleles and ABO Blood Group Antigens

Mustafa Soyöz1, Burcu Akman1, İsmail Totur1, Sinem Topçu1, Aslı Özkızılcık Koçyiğit1, Burcu Çerçi Gürbüz1, Ceren Yüksel1, Toprak Hamdi Güngör1, Ayşe Memon1, Derya Rasime Güleç2, Murat Kılıçoğlu2, Tülay Kılıçaslan Ayna1, Ibrahim Pirim1
1Department of Biology and Genetics, Medical Faculty of İzmir Katip Çelebi University, İzmir, Turkey
2Department of Tissue Typing Laboratory, İzmir Tepecik Training and Research Hospital, İzmir, Turkey

Objectives: This study aims to investigate human leukocyte antigen (HLA) allele frequencies of healthy individuals and to determine whether there is an association between the HLA alleles and ABO blood groups.
Materials and methods: The HLA-A, HLA-B and HLA-DRB1 allele frequency were evaluated in a sample of 450 unrelated individuals at Izmir Tepecik Education and Research Hospital Tissue Typing Laboratory archives. The HLA genotypes of individuals were analyzed by using single-specific primer-polymerase chain reaction (PCR-SSP) or PCR using sequence-specific oligonucleotide (PCR-SSO) methods. Blood groups were evaluated by using microplate agglutination method.
Results: The most common alleles were HLA-A*02, HLA-B*35, and HLA-DRB1*11 in each locus. A and O blood groups were most common, respectively. A statistically significant association between HLA and ABO blood groups was found in HLA-B and HLA-DRB1 loci.
Conclusion: Our study results confirm the other study findings in the Turkish population and also contribute an additional data for further HLA polymorphisms and anthropological studies. We believe that gaining a better understanding on the HLA allele frequencies would help to constitute national transplantation strategies.

Keywords: Allele, blood type, human leukocyte antigen

Corresponding Author: Mustafa Soyöz, Türkiye
Manuscript Language: English
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