Turk J Immunol. 2016; 4(3): 47-51 | DOI: 10.5606/tji.2016.513

Involvement of Sting-Activating Cyclic Di-Nucleotides on T-Cell Differentiation and Function: An Unresolved Issue

Begüm Yýldýz¹, Ýhsan Gürsel¹
Department of Molecular Biology and Genetics, Thorlab, Therapeutic Oligonucleotide Research Laboratory, Bilkent University, Ankara, Turkey

STING is the pivotal mediator for the recognition of host and pathogenic cytosolic dsDNA as well as cyclic di-nucleotide metabolites from microbes. Studies demonstrated that DNA released from cancerous cells are internalized by innate immune cells such as macrophages and dendritic cells in tumor microenvironment and trigger the production of interferon beta and other pro-inflammatory cytokines including interleukin 6, tumor necrosis factor alpha, and interleukin 12 through STING triggered signaling pathway. Later, these cytokines increase the cytotoxic activity of CD8+ T-cells by increasing the production of interferon gamma. This review discusses the importance of the involvement of STING during the establishment of immunity against intracellular pathogens and its direct effect on T-cells.

Keywords: cGAMP; immune response; STING; T-lymphocytes.

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Sting’i Etkinleþtiren Siklik Dinükleotidlerin T Hücre Diferansiyasyonu ve Fonksiyonuna Olan Etkisi: Çözülmemiþ bir Sorun

Begüm Yýldýz¹, Ýhsan Gürsel¹
Department of Molecular Biology and Genetics, Thorlab, Therapeutic Oligonucleotide Research Laboratory, Bilkent University, Ankara, Turkey

STING (Stimulator of interferon genes), hem patojen ve konaðýn kendi sitozolik çift sarmallý DNA (dsDNA)’sýna hem de mikrop kaynaklý siklik di-nükleotidlerin tanýnmasýnda önemli bir mediyatördür. Çalýþmalar, kanser hücrelerinden salýnan DNA’nýn, makrofaj ve dendritik hücreler gibi doðal baðýþýklýk sistemi hücreleri tarafýndan tümör mikro çevresindeki hücrelerce alýndýðýný göstermiþtir. Bu internalizasyon STING’in tetiklediði yolak üzerinden interferon beta, interlökin 6, tümör nekroz faktör alfa ve interlökin 12 gibi diðer pro-enflamatuar sitokinlerin salýmýný yönlendirir. Daha sonra bu sitokinler interferon gama üretimini artýrarak CD8+ T hücrelerinin sitotoksik etkinliklerini artýrýr. Bu derleme STING yolaðýnýn hücre içi patojenlere karþý oluþan immünitedeki rolünü ve T-hücreleri üzerine olasý doðrudan etkilerini tartýþmaktadýr.

Anahtar Kelimeler: Adjuvan; cGAMP; immün cevap; STING; T lenfositleri.

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