Turk J Immunol. 2020; 8(1): 1-5 | DOI: 10.25002/tji.2020.1193

Effect of Physalis minima L. on Interferon-γ and Interleukin-1β Levels in 7,12 Dimethylbenz[a]anthracene Administered Mice

Hary Isnanto¹, Fatiha Kamilah¹, Kurnilia Dewi Astuti¹, Citra Sefrilla Ramadhani¹, Muhaimin Rifai^2
1Biology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang 65145, East Java, Indonesia
²Biosystem Study Center, Brawijaya University, Malang 65145, East Java, Indonesia

Introduction: 7.12-Dimethylbenz[a]anthracene (DMBA) is a carcinogenic substance that can have immunosuppressive effects. Physalis minima L. is one of the herbal medicinal substances that was assumed to modulate immunosuppressive effects in DMBA-induced mice toward interferon γ (IFN-γ) and interleukin-1β (IL-1β).
Materials and Methods: Female BALB/c mice were given DMBA. DMBA-induced mice were administered with Physalis extract, once a day for two weeks. The level of IFN-γ and IL-1β were measured using a flow cytometer.
Results: Physalis minima L. extract was able to increase (p<0.05) the level of IFN-γ in DMBA-given groups. Meanwhile, Physalis minima L. extract could increase the level of IL-1β in group C+D1 (p<0,05).
Conclusions: Physalis minima L. extract could increase the level of IFN-γ and IL-1β in DMBA Induced Mice

Keywords: 7.12-Dimethylbenz[a]anthracene, IFN-γ, IL-1β, Physalis minima L.

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Physalis minima’nýn 7,12 Dimetilbenzantrasen Uygulanmýþ Farelerde Interferon-g ve Ýnterlökin 1β Seviyelerine Olan Etkisi

Hary Isnanto¹, Fatiha Kamilah¹, Kurnilia Dewi Astuti¹, Citra Sefrilla Ramadhani¹, Muhaimin Rifai^2
1Biology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang 65145, East Java, Indonesia
²Biosystem Study Center, Brawijaya University, Malang 65145, East Java, Indonesia

Giriþ: Karsinojenik etkileri olan 7,12-Dimetilbenzantrasen (DMBA) ayný zamanda baðýþýklýk sistemini de baskýlar. Physalis minima’nýn bu baskýlanmayý DMBA verilmiþ farelerde interferon γ (IFN-γ ) ve interlökin 1γ (IFN-1β) yolu ile düzenleyebileceði düþünülmektedir. Gereçler ve
Yöntemler: Diþi BALB/c farelere DMBA verildi. Bu DMBA uygulanmýþ deneklere ayrýca iki hafta boyunca her gün bir kez Physalis ekstresinden verildi. Bu deneklerin IFN-γ ve IFN-1β seviyeleri akan hücre ölçer kullanýlarak ölçüldü.
Bulgular: Physalis minima L ekstresi, DMBA verilmiþ farelerde IFN-γ ve IFN-1β seviyelerini artýrdý (p<0,05).
Sonuçlar: Phsalis minima ekstresi, DMBA uygulanmýþ farelerde IFN-γ ve IFN-1β seviyelerini artýrmaktadýr

Anahtar Kelimeler: 7-12 Dimetilbenzantrasen, IFN-γ, IL-1β, Physalis minima L.

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