Turk J Immunol. 2017; 5(1): 1-4 | DOI: 10.25002/tji.2017.542

Mast Cells in Leprosy Patients with Reversal Reactions

Renni Yunnati¹, Fatihatul FM², Fika A², Prasetyowati S³, Indropo A^4
1Lecturer of Department of Dermatology and Venereology, Medical Faculty Diponegoro University, Semarang, Indonesia.
²Bachelor of Medicine, Medical Faculty Diponegoro University, Semarang, Indonesia.
³Lecturer of Department of Dermatology and Venereology, Medical Faculty Diponegoro University, Semarang, Indonesia.
⁴Lecturer of Department of Dermatology and Venereology, Medical Faculty Airlangga University, Surabaya, Indonesia.

Background: Reversal reaction (RR) is an acute reaction on chronic episode which often contributes to withdrawal of treatment and disability in leprosy patients. Previous study showed that mast cells in reactive tuberculoid lesions biopsy material had lower density than non reactive tuberculoid lesions. Granulomatous lesions in leprosy patients with high mast cells density were more likely to progress into severe reversal reaction. Objective: To examine mast cells level in reversal reaction patients (RR) and non-reactional leprosy patients (non-RR) Methods: Fiftysix leprosy patients consist of 28 with reversal reactions and 28 non-reactional leprosy were assessed for mast cells levels by immunohistochemistry staining. The mast cell numbers in both groups were analyzed using Independent T-test. Results: Mast cells were increased in the reversal group (p<0.05). Conclusion: Mast cells level is associated with reversal reaction of leprosy.

Keywords: Leprosy, reversal reaction, mast cell

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Tip 1 Reaksiyon Pozitif Lepra Hastalarýnda Mast Hücreleri

Renni Yunnati¹, Fatihatul FM², Fika A², Prasetyowati S³, Indropo A^4
1Lecturer of Department of Dermatology and Venereology, Medical Faculty Diponegoro University, Semarang, Indonesia.
²Bachelor of Medicine, Medical Faculty Diponegoro University, Semarang, Indonesia.
³Lecturer of Department of Dermatology and Venereology, Medical Faculty Diponegoro University, Semarang, Indonesia.
⁴Lecturer of Department of Dermatology and Venereology, Medical Faculty Airlangga University, Surabaya, Indonesia.

Giriþ: Tip 1 reaksiyon, genel olarak lepra hastalarýnda hareket kýsýtlýlýðý ve tedavinin kesilmesi ile iliþkili olan, kronik lepra hastalýðýnýn akut bir reaksiyonudur. Çalýþmalar, reaktif tüberküloid lezyonlardan alýnan biopsi materyallerinde, reaktif olmayan tüberküloid lezyonlarýndakine göre daha az mast hücresi olduðunu göstermiþtir.Lepra hastalarýnýn granülomatöz lezyonlarýndanda dansitesi çok yüksek olarak saptanan mast hücreleri, muhtemelen Tip 1 reaksiyona neden olmaktadýr. Amaç: Tip 1 reaksiyon gösteren hastalar ile göstermeyen hastalarýn mast hücresi düzeylerini araþtýrmak. Yöntemler: Reaksiyonu oaln 28 hasta ile reaksiyon göstermeyen diðer 28 hasta, immünhistokimya boyamasý ile saptanan mast hücreleri açýsýndan irdelendi. Her iki gruptaki mast hücresi sayýlarý, Student-t testi ile karþýlaþtýrýldý. Bulgular: Reaskiyon gösteren grupta mast hücreleri istatistiksel olarak anlamlý düzeyde daha fazla idi (p<0.05). Sonuç: Lepra hastalarýnda, mast hücreleri tip 1 reaksiyon ile iliþkilidir.

Anahtar Kelimeler: Lepra, Tip 1 reaksiyon, mast hücresi

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