CURRENT ISSUE
Editorial
Highlights from This Issue and Perspectives for the New Year
Günnur Deniz
It is my pleasure to introduce the current issue of the Turkish Journal of Immunology, which brings together a series of original studies reflecting continued scientific progress in our field. This issue features contributions from Türkiye (4 articles), Indonesia (1 article), and Saudi Arabia (1 article), demonstrating both the journal’s expanding international engagement and the strong research activity (...)
Review Article
Role of Circular RNAs in Cancer Immune Checkpoint Therapy: Focus on Anti-PD-1 Treatment
Duygu Kırkık
Immunotherapies refer to the usage of stimulative or suppressive substances in order to change the outcomes of immune system interactions and antagonize the disease progression. In cancer immunotherapies, it is provided by cancer vaccines, adoptive cell therapies with tumor-infiltrating lymphocytes, chimeric antigen receptor (CAR) T-cell therapies, (...)
and others
Original Research
Understanding Allosteric Stabilization of pMHC by Peptide Ligands Through Molecular Dynamics Simulations
Onur Serçinoğlu
The adaptive immune response is a critical component of the immune system, providing highly specific and long-lasting protection against pathogens. Cytotoxic T lymphocytes play a crucial role in this response by eliminating infected or cancerous cells. Cytotoxic T lymphocytes (...)
Integrated Clinical and In Silico Analysis of Hypomorphic DCLRE1C Variants: Predicting Malignancy and Autoimmunity Risk
Serkan Küççüktürk
The Artemis protein, encoded by the DNA cross-link repair 1C (DCLRE1C) gene, plays a critical role in variable, diversity, and joining [V(D)J] recombination and in the repair of non-homologous end joining (NHEJ) DNA double-strand breaks. Pathogenic variants (...)
and others
Dose-Dependent Effects of Maternal Vitamin D₃ on Offspring IL-6 and IL-1β in a Rat Model
Kurnia Maidarmi Handayani
Vitamin D₃ deficiency is a significant health concern during pregnancy and lactation due to its potential long-term effects on both maternal and neonatal health. Vitamin D₃ supports calcium homeostasis, immune development, and inflammation regulation. Low maternal vitamin (...)
and others
Effects of Typeable and Non-typeable Haemophilus influenzae on Human CD4+ T Cell Proliferation and Production of Th1 and Th2 Cytokines
Abdel Rahman Youssef
Haemophilus influenzae bacterium inhabits the upper respiratory tract and may cause local and systemic diseases. Haemophilus influenzae strains are classified into capsulate or typeable H. influenzae (THi) and acapsulate or non-typeable H. influenzae (NTHi) based on the expression of a polysaccharide capsule. Typeable H. influenzae (...)
Effects of HLA Typing Resolution on Hardy-Weinberg Equilibrium, Linkage Disequilibrium, and Hidden Heterozygosity
Emel Yantır
The human leukocyte antigen (HLA) complex, encoded by the major histocompatibility complex (MHC), is characterized by its remarkable polymorphism and linkage disequilibrium (LD), which makes it crucial for both immunity and disease susceptibility. Balancing selection, which promotes a heterozygote advantage and enhances resistance to infection, is the main evolutionary force maintaining this (...)