Introduction:

Vitamin D is very important for Type 1 diabetes mellitus (T1 DM) pathogenesis, and plays major role in the regulation of pancreatic beta cells. However, serum vitamin D (25(OH)D₃) level related to inflammatory condition in T1 DM has not been sufficiently investigated. Therefore, we aimed to investigate the relationship between serum vitamin D (25(OH)D₃), C-Peptide, and Interleukin-2 levels in children with T1 DM.

Material and Methods:

Blood samples from 20 subjects of T1 DM patients and healthy patients were collected, and analyzed. Serum level of vitamin D (25(OH)D₃), C-Peptide, and Interleukin-2 between two groups were measured by using Indirect ELISA.

Results:

Serum vitamin D (25(OH)D₃), C-Peptide, and Interleukin-2 level between both groups were significantly different (p<0.001). It was shown that serum vitamin D (25(OH)D₃) and C-Peptide level had significant positive correlation, while serum C-Peptide and Interleukin-2 level had significant negative correlation (p=0.002; r=-0.658). Serum vitamin D (25(OH)D₃) and Interleukin-2 had also significant negative correlation (p<0.001; r=-0.753).

Discussion:

Serum vitamin D (25(OH)D₃) level is related to inflammatory condition in T1 DM. Low level of serum vitamin D (25(OH)D₃) in T1 DM patient tends to increase the level of Inteleukin-2, and it is highly correlated with pancreatic beta cells’ impairment, which is marked by low C-Peptide level and high Inteleukin-2 level.

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