Hary Isnanto
Fatiha Kamilah
Kurnilia Dewi Astuti
Citra Sefrilla Ramadhani
Muhaimin Rifa’i

Abstract

Introduction:

7.12-Dimethylbenz[a]anthracene (DMBA) is a carcinogenic substance that can have immunosuppressive effects. Physalis minima L. is one of the herbal medicinal substances that was assumed to modulate immunosuppressive effects in DMBA-induced mice toward interferon γ (IFN-γ) and interleukin-1β (IL-1β).

Materials and Methods:

Female BALB/c mice were given DMBA. DMBA-induced mice were administered with Physalis extract, once a day for two weeks. The level of IFN-γ and IL-1β were measured using a flow cytometer.

Results:

Physalis minima L. extract was able to increase (p<0.05) the level of IFN-γ in DMBA-given groups. Meanwhile, Physalis minima L. extract could increase the level of IL-1β in group C+D1 (p<0,05).

Conclusions:

Physalis minima L. extract could increase the level of IFN-γ and IL-β in DMBA Induced Mice.

Keywords:

7.12-Dimethylbenz[a]anthracene, IFN--γ, IL-1β, Physalis minima L.

VOLUME

8

,

ISSUE

1
April 2020

Correspondence

Hary Isnanto

Email

Received

Accepted

Published

Suggested Citation

DOI

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This work is licensed under the Creative Commons Attribution-NonCommercial-Non-Derivatives 4.0 International License (CC BY-NC-ND 4.0). License