Introduction:

Muscle wasting is an extrapulmonary manifestation that occurs in 20–40% of patients with Chronic Obstructive Pulmonary Disease (COPD). The purpose of this study is to confirm whether nutrition support can improve inflammation (measured by levels of TNF-_α, CRP, leptin, and adiponectin), muscle wasting, and quality of life of COPD patients with muscle wasting.

Material and Methods:

The study design was a clinical pre-and post-auto-control quasi-experimental, conducted with a sample of stable COPD patients with comorbid muscle wasting. Muscle wasting was diagnosed through examination of the Bioelectrical Impedance Analysis (BIA). Levels of leptin and adiponectin were measured using the Enzyme- linked immunosorbent assay (ELISA) method, and quality of life was assessed using COPD Assessment Test (CAT) score. BIA, TNF-_α, CRP, leptin, adiponectin, and CAT were measured in 32 COPD patients with muscle wasting, before and after 12 weeks supplementation with Ophiocephalus striatus extract, 3x1000 mg/day.

Results:

There was a significant increase in body-mass index (BMI) (p=0.046), no significant increase in Fat-free mass index (FFMI) (p=0506), no significant decrease in TNF-_α and CRP, a significant decrease in leptin levels (p <0.001), a significant increase in adiponectin levels (p=0.048), and a significant improvement in quality of life (score CAT) (p<0.001) after administration of Ophiocephalus striatus extract for 12 weeks.

Conclusion:

Supplementation with Ophiocephalus striatus extract for 12 weeks can improve BMI, decrease levels of TNF-_α, CRP, and leptin, increase the level of adiponectin, and result in improvement in the quality of life of stable COPD patients with muscle wasting.

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