Objective:

Tuberculosis (TB), which continues to be a global health problem, is under the influence of environmental factors and host genetic factors. In this study, -1478CA/del (rs33989964) located in the cytokine signal suppressor (SOCS)-1 gene promoter region and 1335G/C (rs11549428) located in the exon-2 region of single nucleotide polymorphisms (single nucleotide polymorphism - SNP) in TB patients. It was aimed to investigate the relationship between susceptibility or resistance to TB.

Materials and Methods:

The study included 90 TB patients with Mycobacterium tuberculosis complex isolated in the culture of clinical specimens and 90 healthy blood donors as a control group. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods were used to determine the investigated SNPs.

Results:

-1478CA/del SNP was found in Hardy-Weinberg balance in the patient and healthy control group. There was no statistically significant relationship between the groups in terms of allele frequency (p=0.327) and genotype distribution (p=0.291). According to the PCR-RFLP results of 1335G/C SNP, the presence of the C allele was detected in all patient and control groups, statistical evaluation could not be performed.

Conclusion:

As a result of our study, no relationship was found between SNPs investigated in the SOCS-1 gene region and resistance or susceptibility to TB. For this study, it should be kept in mind that there may be different polymorphisms on the SOCS-1 gene, which is not the subject of our research but needs to be investigated.

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